Time-restricted diets, including intermittent fasting, enhance Alzheimer’s sufferers’ cognition and sleep. A UC San Diego School of Medicine study revealed that time-restricted meal programs boosted cognition and reduced brain amyloid protein. The discoveries may enable a human clinical study. The study also found that mice given a rigorous schedule expressed Alzheimer’s disease and neuroinflammation genes differently…
A recent study suggests intermittent fasting may enhance Alzheimer’s patients’ sleep and mental performance.
Animal studies have demonstrated that a time-restricted diet, a sort of intermittent fasting that restricts the daily eating window without reducing food intake, can reset the body’s biological clock in Alzheimer’s patients.
Around 80% of Alzheimer’s patients have sleep disorders such nighttime cognitive deterioration, evening disorientation, and trouble sleeping and keeping asleep.
University of California (UC) San Diego School of Medicine researchers found that mice can correct Alzheimer’s disease-related circadian abnormalities.
The Cell Metabolism research found that time-restricted feeding improved mice’s memory and decreased amyloid protein production.
The discoveries will likely lead to a human clinical trial, say specialists.
“We thought circadian disruptions in Alzheimer’s patients were caused by neurodegeneration, but we’re now learning they may be one of the main drivers of pathology,” said senior study author and UC San Diego School of Medicine neuroscience professor Paula Desplats.
She remarked, “Our findings provide proof-of-concept for a simple and practical method to address these disturbances.”
In an Alzheimer’s disease mouse model, researchers fed the mice on a time-restricted regimen and limited their daily meals to six hours.
Humans would fast 14 hours a day.
Time-restricted mice showed greater memory, less nighttime hyperactivity, a more regular sleep pattern, and less sleep disruptions than control mice fed 24/7.
The time-restricted feeding strategy reduced Alzheimer’s disease behavior, as test mice had higher cognitive scores than controls.
“Anything we can do to help patients restore their circadian rhythm will make a huge difference in how we manage Alzheimer’s in the clinic and how caregivers manage it at home,” said Desplats.
The researchers also enhanced the mice’s molecular changes.
The researchers found that schedule-fed mice expressed several Alzheimer’s disease and neuroinflammation genes differently.
They also found that the eating plan reduced brain amyloid protein. Well-known Alzheimer’s disease symptoms include amyloid deposition.
Desplats said, “Time-restricted feeding is a strategy that people can easily and immediately integrate into their lives.”
Conclusion:-
Alzheimer’s patients benefit from a time-restricted diet to reset their biological clock. A University of California San Diego School of Medicine study found that time-restricted feeding improved mice’s memory and decreased amyloid protein formation. The discoveries may enable a human clinical study. The mice were fed a six-hour meal, resulting in a 14-hour fast. The mice showed greater memory, reduced nighttime hyperactivity, more regular sleep, and fewer sleep interruptions. Researchers found that mice given a rigid schedule expressed genes related with Alzheimer’s disease and neuroinflammation differently. The eating plan significantly reduced brain amyloid protein accumulation, a hallmark of Alzheimer’s.
