A team of international experts, including an Allahabad University (AU) alumni, uncovered a tobacco leaf chemical that may fight numerous cancers.
The findings are noteworthy given tobacco smoking causes 25% of cancer deaths globally and is the leading cause of lung cancer, according to WHO.
The UK Taylor & Francis Ltd. journal “Journal of Biomolecular Structure and Dynamics” reported the amazing finding by AU alumni Amit Dubey, Indian scientist Aisha Tufail, and Malaysian researchers Miah Roney and Prof A K M Moyeenul Huq.
A single anti-cancer molecule called “4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline” may be isolated from tobacco leaves without adverse effects, according to the study.
Amit Dubey said, “The epidermal growth factor receptor (EGFR) influences cancer cell proliferation, survival, adhesion, migration, and differentiation. The tumor cell walls contain EGFR. This protein is essential for survival and growth.”
Working together, the researchers screened drug bank molecules targeting EGFR.
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The drug bank, a comprehensive, free-access online database managed by the University of Alberta and the Metabolomics Innovation Centre in Alberta, Canada, helped the scientists find the tobacco leaf chemical for their investigation. Senior scientist Amit works at Quanta Calculus Pvt Ltd in Greater Noida.
A tobacco leaf chemical developed by AU alumnus and colleagues may fight numerous cancers. The Taylor and Francis Ltd. “Journal of Biomolecular Structure and Dynamics” study discovered that tobacco leaves may be used to extract a single anti-cancer chemical, “4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline” without negative effects. The chemical, which targets EGFR, is essential for cancer cell proliferation, survival, adhesion, migration, and differentiation. Working together, the researchers screened drug bank molecules targeting EGFR. The University of Alberta and Metabolomics Innovation Centre’s drug bank, a comprehensive, free-access online database, provided the chemical.